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The effect of thiazolidinediones on body fat redistribution in adults: A systematic review and meta-analysis of randomized controlled trials.
Zhang, Fang; Pan, Xiaohui; Zhang, Xinyue; Tong, Nanwei.
Affiliation
  • Zhang F; Division of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
  • Pan X; Division of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
  • Zhang X; Division of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
  • Tong N; Division of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Obes Rev ; 25(3): e13675, 2024 Mar.
Article in En | MEDLINE | ID: mdl-38098209
ABSTRACT
Visceral adiposity is a strong predictor of cardiometabolic risk. Thiazolidinediones (TZDs) are associated with a shift in fat redistribution from visceral adipose tissue (VAT) to subcutaneous adipose tissue (SAT). We aimed to compare the effects of TZD and other interventions on fat remodeling in adults in randomized controlled trials. Among the 1331 retrieved studies, 39 trials with 1765 participants were included in the meta-analysis. The standardized mean difference in VAT change was not significantly different between TZD and comparators across the overall studies. Intriguingly, TZD treatment resulted in significant decreases in VAT compared with placebo and sulfonylureas (p < 0.05), although recombinant human growth hormone was superior to TZD regarding VAT reduction (p < 0.05). Data from 216 participants showed TZD leading to a greater reduction in liver fat percentage than comparators (p < 0.05). Compared with the controls, TZD significantly increased SAT, total body fat, weight, waist circumference, and body mass index (p < 0.05). However, TZD pronouncedly improved glucose control, insulin resistance, adiponectin, and lipid profile (p < 0.05). TZD provides a favorable effect on fat redistribution and benefits insulin sensitivity, suggesting a potentially valuable approach in cardiometabolic risk management.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Cardiovascular Diseases / Thiazolidinediones Type of study: Systematic_reviews Limits: Adult / Humans Language: En Journal: Obes Rev Journal subject: METABOLISMO Year: 2024 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Cardiovascular Diseases / Thiazolidinediones Type of study: Systematic_reviews Limits: Adult / Humans Language: En Journal: Obes Rev Journal subject: METABOLISMO Year: 2024 Document type: Article Affiliation country: Country of publication: